Some mosquito-borne viruses turn mice into alluring mosquito bait.
Mice infected with dengue or Zika viruses — and people infected with dengue — emit a flowery, orange-smelling chemical that tempts hungry mosquitoes, researchers report June 30 in Cell. In mice, the infections spur the growth of skin-inhabiting bacteria that make the chemical, drawing in bloodsucking Aedes aegypti mosquitoes that could then transmit the viruses to new hosts, including humans.
Previous studies showed that other mosquito species prefer to feed on animals carrying the parasite that causes malaria (SN: 2/9/17). But it was unknown whether the same was true for viruses such as dengue or Zika, says Gong Cheng, a microbiologist at Tsinghua University in Beijing.
The chemical acetophenone — which to humans smells like orange blossom — may be that lure. Mice infected with dengue or Zika viruses give off approximately 10 times more acetophenone and attract more mosquitoes than uninfected animals, Cheng and colleagues found. People infected with dengue similarly release more of the chemical than healthy people. Samples of odors taken from the armpits of infected people also created potent mosquito magnets when smeared on filter paper attached to a volunteer’s palm. Acetophenone typically comes from bacteria. Researchers found that Bacillus bacteria on mice were the likely culprits producing the chemical. An infection stops mice from making an antimicrobial protein called RELMα, allowing the acetophenone-emitting microbes to flourish.
But a component of some acne medications can bring back RELMα in mice, the team found. Infected animals fed a derivative of vitamin A called isotretinoin produced less acetophenone and become less attractive mosquito targets.
It’s possible that giving people isotretinoin could help reduce virus transmission among people by hiding infected people from the bloodsucking insects, Cheng says. He and colleagues are planning to test the strategy in Malaysia, where dengue circulates.
We’ve now seen farther, deeper and more clearly into space than ever before.
A stellar birthplace, a nebula surrounding a dying star, a group of closely interacting galaxies, the first spectrum of an exoplanet’s light. These are some of the first images from the James Webb Space Telescope, released in a NASA news briefing on July 12. This quartet of cosmic scenes follows on the heels of the very first image released from the telescope, a vista of thousands of distant galaxies, presented in a White House briefing on July 11. “First of all, it’s really gorgeous. And it’s teeming with galaxies,” said JWST Operations Scientist Jane Rigby at the July 12 briefing. “That’s been true of every image we’ve taken with Webb. We can’t take [an image of] blank sky. Everywhere we look, there’s galaxies everywhere.”
Going deep The galaxies captured in the first released image lie behind a cluster of galaxies about 4.6 billion light-years away. The mass from those closer galaxies distorts spacetime in such a way that objects behind the cluster are magnified, giving astronomers a way to peer more than 13 billion years into the early universe.
Even with that celestial assist, other existing telescopes could never see so far. But the James Webb Space Telescope, also known as JWST, is incredibly large — at 6.5 meters across, its mirror is nearly three times as wide as that of the Hubble Space Telescope. It also sees in the infrared wavelengths of light where distant galaxies appear. Those features give it an edge over previous observatories.
“There’s a sharpness and a clarity we’ve never had,” said Rigby, of NASA’s Goddard Space Flight Center in Greenbelt, Md. “You can really zoom in and play around.” Although that first image represents the deepest view of the cosmos to date, “this is not a record that will stand for very long,” astronomer Klaus Pontoppidan of the Space Telescope Science Institute in Baltimore said in a June 29 news briefing. “Scientists will very quickly beat that record and go even deeper.”
But JWST wasn’t built only to peer deeper and farther back in time than ever before. The cache of first images and data showcases space scenes both near and far, glimpses of single stars and entire galaxies, and even a peek into the chemical composition of a far-off planet’s atmosphere.
“These are pictures just taken over a period of five days. Every five days, we’re getting more data,” European Space Agency science advisor Mark McCaughrean said at the July 12 briefing. (JWST is an international collaboration among NASA, ESA and the Canadian Space Agency.) “It’s a culmination of decades of work, but it’s just the beginning of decades. What we’ve seen today with these images is essentially that we’re ready now.” Cosmic cliffs This image shows the “Cosmic Cliffs,” part of the enormous Carina nebula, a region about 7,600 light-years from Earth where many massive stars are being born. Some of the most famous Hubble Space Telescope images feature this nebula in visible light, but JWST shows it in “infrared fireworks,” Pontoppidan says. JWST’s infrared detectors can see through dust, so the nebula appears especially spangled with stars. “We’re seeing brand new stars that were previously completely hidden from our view,” said NASA Goddard astrophysicist Amber Straughn.
But molecules in the dust itself are glowing too. Energetic winds from baby stars in the top of the image are pushing and sculpting the wall of gas and dust that runs across the middle. “We see examples of bubbles and cavities and jets that are being blown out from newborn stars,” Straughn said. And gas and dust are the raw material for new stars — and new planets.
“It reminds me that our sun and our planets, and ultimately us, were formed out of this same stuff that we see here,” Straughn said. “We humans really are connected to the universe. We’re made out of the same stuff.” Foamy nebula The Southern Ring nebula is an expanding cloud of gas that surrounds a dying star about 2,000 light-years from Earth. In previous Hubble images, the nebula looks like an oblong swimming pool with a fuzzy orange deck and a bright diamond, a white dwarf star, in the middle. JWST expands the view far beyond that, showing more tendrils and structures in the gas than previous telescopes could see. “You see this bubbly, almost foamy appearance,” said JWST astronomer Karl Gordon, of the Space Telescope Science Institute. In the left hand image, which captures near-infrared light from JWST’s NIRCam instrument, the foaminess traces molecular hydrogen that formed as dust expanded away from the center. The center appears blue due to hot ionized gas heated by the leftover core of the star. Rays of light escape the nebula like the sun peeking through patchy clouds.
In the right-hand image, taken by the MIRI mid-infrared camera, the outer rings look blue and trace hydrocarbons forming on the surface of dust grains. The MIRI image also reveals a second star in the nebula’s core.
“We knew this was a binary star, but we didn’t see much of the actual star that produced this nebula,” Gordon said. “Now in MIRI this star glows red.” A galactic quintet Stephan’s Quintet is a group of galaxies about 290 million light-years away that was discovered in 1877. Four of the galaxies are engaged in an intimate gravitational dance, with one member of the group passing through the core of the cluster. (The fifth galaxy is actually much closer to Earth and just appears in a similar spot on the sky.) JWST’s images show off more structure within the galaxies than previous observations did, revealing where stars are being born.
“This is a very important image and area to study,” because it shows the sort of interactions that drive the evolution of galaxies, said JWST scientist Giovanna Giardino of the European Space Agency.
In an image from the MIRI instrument alone, the galaxies look like wispy skeletons reaching towards each other. Two galaxies are clearly close to merging. And in the top galaxy, evidence of a supermassive black hole comes to light. Material swirling around the black hole is heated to extremely high temperatures and glows in infrared light as it falls into the black hole. An exoplanet’s sky This “image” is clearly different from the others, but it’s no less scientifically exciting. It shows the spectrum of light from the star WASP 96 as it passes through the atmosphere of its gas giant planet, WASP 96b.
“You get a bunch of what looks like bumps and wiggles to some people but it’s actually full of information content,” said NASA exoplanet scientist Knicole Colón. “You’re actually seeing bumps and wiggles that indicate the presence of water vapor in the atmosphere of this exoplanet.” The planet is about half the mass of Jupiter and orbits its star every 3.4 days. Previously astronomers thought it had no clouds in its sky, but the new data from JWST show signs of clouds and haze. “There is evidence of clouds and hazes because the water features are not quite as large as we predicted,” Colón said. A long time coming These first images and data have been a very long time coming. The telescope that would become JWST was first dreamed up in the 1980s, and the planning and construction suffered years of budget issues and delays (SN: 10/6/21).
The telescope finally launched on December 25. It then had to unfold and assemble itself in space, travel to a gravitationally stable spot about 1.5 million kilometers from Earth, align its insectlike primary mirror made of 18 hexagonal segments and calibrate its science instruments (SN: 1/24/22). There were hundreds of possible points of failure in that process, but the telescope unfurled successfully and got to work.
“We are so thrilled that it works because there’s so much at risk,” says JWST senior project scientist John Mather of NASA’s Goddard Space Flight Center. “The world has trusted us to put our billions into this and make it go, and it works. So it’s an immense relief.” In the months following, the telescope team released teasers of imagery from calibration, which already showed hundreds of distant, never-before-seen galaxies. But the images now being released are the first full-color pictures made from the data scientists will use to start unraveling mysteries of the universe.
“It sees things that I never dreamed were out there,” Mather says.
For the telescope team, the relief in finally seeing the first images was palpable. “It was like, ‘Oh my god, we made it!’” says image processor Alyssa Pagan, also of Space Telescope Science Institute. “It seems impossible. It’s like the impossible happened.”
In light of the expected anticipation surrounding the first batch of images, the imaging team was sworn to secrecy. “I couldn’t even share it with my wife,” says Pontoppidan, leader of the team that produced the first color science images.
“You’re looking at the deepest image of the universe yet, and you’re the only one who’s seen that,” he says, of the first picture released July 11. “It’s profoundly lonely.” Soon, though, the team of scientists, image processors and science writers was seeing something new every day for weeks as the telescope downloaded the first images. “It’s a crazy experience,” Pontoppidan says. “Once in a lifetime.”
For Pagan, the timing is perfect. “It’s a very unifying thing,” she says. “The world is so polarized right now. I think it could use something that’s a little bit more universal and connecting. It’s a good perspective, to be reminded that we’re part of something so much greater and beautiful.”
JWST is just getting started as it now begins its first round of full science operations. “There’s lots more science to be done,” Mather says. “The mysteries of the universe will not come to an end anytime soon.”
There is a galaxy spinning like a record in the early universe — far earlier than any others have been seen twirling around.
Astronomers have spotted signs of rotation in the galaxy MACS1149-JD1, JD1 for short, which sits so far away that its light takes 13.3 billion years to reach Earth. “The galaxy we analyzed, JD1, is the most distant example of a rotational galaxy,” says astronomer Akio Inoue of Waseda University in Tokyo. “The origin of the rotational motion in galaxies is closely related to a question: how galaxies like the Milky Way formed,” Inoue says. “So, it is interesting to find the onset of rotation in the early universe.”
JD1 was discovered in 2012. Due to its great distance from Earth, its light had been stretched, or redshifted, into longer wavelengths, thanks to the expansion of the universe. That redshifted light revealed that JD1 existed just 500 million years after the Big Bang.
Astronomers used light from the entire galaxy to make that measurement. Now, using the Atacama Large Millimeter/submillimeter Array in Chile for about two months in 2018, Inoue and colleagues have measured more subtle differences in how that light is shifted across the galaxy’s disk. The new data show that, while all of JD1 is moving away from Earth, its northern part is moving away slower than the southern part. That’s a sign of rotation, the researchers report in the July 1 Astrophysical Journal Letters.
JD1 spins at about 180,000 kilometers per hour, roughly a quarter the spin speed of the Milky Way. The galaxy is also smaller than modern spiral galaxies. So JD1 may be just starting to spin, Inoue says.
The James Webb Space Telescope will observe JD1 in the next year to reveal more clues to how that galaxy, and others like ours, formed (SN: 10/6/21).
No beast on Earth is tougher than the tiny tardigrade. It can survive being frozen at -272° Celsius, being exposed to the vacuum of outer space and even being blasted with 500 times the dose of X-rays that would kill a human.
In other words, the creature can endure conditions that don’t even exist on Earth. This otherworldly resilience, combined with their endearing looks, has made tardigrades a favorite of animal lovers. But beyond that, researchers are looking to the microscopic animals, about the size of a dust mite, to learn how to prepare humans and crops to handle the rigors of space travel. The tardigrade’s indestructibility stems from its adaptations to its environment — which may seem surprising, since it lives in seemingly cushy places, like the cool, wet clumps of moss that dot a garden wall. In homage to such habitats, along with a pudgy appearance, some people call tardigrades water bears or, adorably, moss piglets.
But it turns out that a tardigrade’s damp, mossy home can dry out many times each year. Drying is pretty catastrophic for most living things. It damages cells in some of the same ways that freezing, vacuum and radiation do.
For one thing, drying leads to high levels of peroxides and other reactive oxygen species. These toxic molecules chisel a cell’s DNA into short fragments — just as radiation does. Drying also causes cell membranes to wrinkle and crack. And it can lead delicate proteins to unfold, rendering them as useless as crumpled paper airplanes. Tardigrades have evolved special strategies for dealing with these kinds of damage. As a tardigrade dries out, its cells gush out several strange proteins that are unlike anything found in other animals. In water, the proteins are floppy and shapeless. But as water disappears, the proteins self-assemble into long, crisscrossing fibers that fill the cell’s interior. Like Styrofoam packing peanuts, the fibers support the cell’s membranes and proteins, preventing them from breaking or unfolding.
At least two species of tardigrade also produce another protein found in no other animal on Earth. This protein, dubbed Dsup, short for “damage suppressor,” binds to DNA and may physically shield it from reactive forms of oxygen.
Emulating tardigrades could one day help humans colonize outer space. Food crops, yeast and insects could be engineered to produce tardigrade proteins, allowing these organisms to grow more efficiently on spacecraft where levels of radiation are elevated compared with on Earth.
Scientists have already inserted the gene for the Dsup protein into human cells in the lab. Many of those modified cells survived levels of X-rays or peroxide chemicals that kill ordinary cells (SN: 11/9/19, p. 13). And when inserted into tobacco plants — an experimental model for food crops — the gene for Dsup seemed to protect the plants from exposure to a DNA-damaging chemical called ethyl methanesulfonate. Plants with the extra gene grew more quickly than those without it. Plants with Dsup also incurred less DNA damage when exposed to ultraviolet radiation. Tardigrades’ “packing peanut” proteins show early signs of being protective for humans. When modified to produce those proteins, human cells became resistant to camptothecin, a cell-killing chemotherapy agent, researchers reported in the March 18 ACS Synthetic Biology. The tardigrade proteins did this by inhibiting apoptosis, a cellular self-destruct program that is often triggered by exposure to harmful chemicals or radiation.
So if humans ever succeed in reaching the stars, they may accomplish this feat, in part, by standing on the shoulders of the tiny eight-legged endurance specialists in your backyard.
Pig hearts beat for three days inside the chests of two brain-dead patients who were kept alive using ventilators. The feat helps researchers prepare for future clinical trials of pig-to-human transplants, surgeons at the NYU Langone Health in New York City announced at a news conference on July 12.
In mid-June, surgeons transplanted a heart from a genetically modified pig into Lawrence Kelly — a 72-year-old Vietnam veteran with a history of heart problems. A second patient received a porcine heart on July 6. The team monitored both patients for 72 hours before taking them off life support.
For those three days, the hearts kept the recently deceased patients’ blood flowing. “We learned a tremendous amount from the first operation,” surgeon Nader Moazami said at the news conference. The new heart was too small for Kelly’s chest. So surgeons had to adjust blood vessels to account for the size mismatch and blood flow wasn’t perfect. Last year, another team at NYU Langone Health transplanted a pig kidney into a brain-dead woman (SN: 10/22/21). The first pig-to-human heart transplant happened in a living patient in January: 57-year-old David Bennet survived two months with a pig heart before dying of heart failure (SN: 1/31/22). All the organs had been genetically modified to avoid immediate rejection by the body and make them safe for people.
It’s unclear why Bennet’s new heart ultimately failed. Transplanting organs into brain-dead people allows for in-depth analyses that aren’t possible in living patients, NYU Langone surgeon Robert Montgomery said. Researchers can take tissue samples and pictures of the organ immediately following the procedure, while the focus for living people is on keeping them alive and comfortable.
Next, the team plans to do longer-term transplants in more brain-dead patients to determine how long pig hearts might last.
Bees that land on short, wide flowers can fly away with an upset stomach.
Common eastern bumblebees (Bombus impatiens) are more likely to catch a diarrhea-inducing gut parasite from purple coneflowers, black-eyed Susans and other similarly shaped flora than other flowers, researchers report in the July Ecology. Because parasites and diseases contribute to bee decline, the finding could help researchers create seed mixes that are more bee-friendly and inform gardeners’ and land managers’ decisions about which flower types to plant. The parasite (Crithidia bombi) is transmitted when the insects accidentally ingest contaminated bee feces, which “tends to make the bees dopey and lethargic,” says Rebecca Irwin, a community and evolutionary ecologist at North Carolina State University in Raleigh. “It isn’t the number one bee killer out there,” but bees sickened with it can struggle with foraging.
In laboratory experiments involving caged bees and 16 plant species, Irwin and her colleagues studied how different floral attributes affected transmission of the gut parasite. They focused on three factors of transmission: the amount of poop landing on flowers when bees fly and forage, how long the parasite survives on the plants and how easily the parasite is transmitted to new bees. Multiplied together, these three factors show the overall transmission rate.
Compared with plants with long, narrow flowers like phlox and bluebeards, short, wide flowers had more feces land on them and transmitted the parasite more easily to the pollinators, increasing the overall parasite transmission rate for these flowers. However, parasite survival times were reduced on these blooms. This is probably due to the open floral shapes increased exposure to ultraviolet light, speeding the drying out of parasite-laden “fecal droplets,” Irwin says.
The findings confirm a new theory suggesting that traits, such as flower shape, are better predictors of disease transmission than individual species of plants, says Scott McArt, an entomologist focusing on pollinator health at Cornell University who wasn’t involved with the study. Therefore, “you don’t need to know everything about every plant species when designing your pollinator-friendly garden or habitat restoration project.”
Instead, to limit disease transmission among bees, it’s best to choose plants that have narrower, longer flowers, he says. “Wider and shorter flowers are analogous to the small, poorly ventilated rooms where COVID is efficiently transmitted among humans.”
If ripping out coneflowers or black-eyed Susans isn’t palatable, don’t fret. Irwin recommends continuing to plant a diversity of flower types. This helps if one type of flower is “a high transmitting species,” she notes. In the future, she plans to conduct field experiments examining other factors that could influence parasite transmission, such as whether bees are driven to visit certain types of flowers more often in nature.
As a journalist covering COVID-19, I’ve had a front-row seat to the pandemic. I’ve been overwhelmed with despair over the death and suffering. I’ve been numb, trying to keep up with the deluge of COVID-19 studies. One balm has been the understanding of colleagues who also report on COVID-19.
I found solace too in Virology, microbiologist Joseph Osmundson’s book of 11 wide-ranging essays, in which he writes of the pandemic and calls for “a new rhetoric of care.” Osmundson includes journal entries from the pandemic, and some of his experiences are similar to mine. He dreams he’s at a gathering where no one is masked. He too felt the “density” of the pandemic: “Emotionally dense, with loss and struggle and even sometimes joy,” he writes. “Scientifically dense, with papers and pre-prints out every day that need reading and some analysis.”
Osmundson doesn’t just focus on the coronavirus. He jumps from other viruses and the immune system to illness and metaphors for illness, to sex and HIV, to archiving history and whose stories get told. Parts of the book feel like an anthology, with quotes from many writers who have weighed in on these topics. Parts are a call to care for everyone, regardless of race, ethnicity, wealth or who one loves. Overall, Osmundson questions how society thinks about viruses. “Viruses … are not evil, they don’t invade. They just are,” he writes. “The meaning we give a virus affects how we live with it.” When we describe viruses as enemies and illness as a war, it “assumes the necessity of casualties.” He argues instead to focus resources on caring for one another.
Born in the early 1980s, Osmundson, a gay man, is acutely aware of the messages that come with viruses. “Our generation of gay men came after the plague,” he writes. “HIV didn’t just kill bodies. It killed a type of sex as well, a type of pleasure.” But new therapies have saved lives and altered perceptions. Pre-exposure prophylaxis can prevent infection, while treatment can render HIV untransmissible (SN: 11/15/19). These advances changed our relationship with the virus, Osmundson writes. “I used to think that HIV would make it harder to find love and sex. Now we know that HIV-positive and undetectable is safe. It’s sexy.”
But the biomedicine that can change our relationship with viruses has not been wielded equitably, Osmundson observes. He returns throughout the book to our common humanity. “That fact of all our bodies, vulnerable together, necessitates mutual care.”
