Floral curve test shows what’s great for a moth is not so good for a flower

PORTLAND, ORE. — A great flower shape for a moth trying to get a drink in the dark turns out to be awful from the plant’s point of view.

Offering hawk moths (Manduca sexta) a range of 3-D printed flowers with different curvatures shows that a moderately curved trumpet shape lets moths sip most efficiently, Foen Peng reported June 24 at the Evolution 2017 meeting. That’s a win for a nocturnal flying insect searching for nectar.
Yet drinking ease wasn’t best for the plant. During swift sips, the moths did less inadvertent bumping against the artificial flowers’ simulated sex organs than moths struggling to sip from an inconvenient shape. Less contact with real flower parts would mean less delivery and pickup of pollen.

Peng, of the University of Washington in Seattle, offered the moths three other shapes besides the gently curved trumpet. The best for the plant was a flat-topped “flower” with a right angle drop to a nectar well in the center. Previous work suggested that lack of curves made it very difficult for hawk moths hovering above a flower and extending their tonguelike proboscises to tap and probe the way to nectar in dim light.

Pollination at first glance may look like an easy mutualism evolving with the best interests of both plant and pollinator. But these experiments reveal a hidden, underlying conflict, Peng said.

Add penis bacteria to the list of HIV risk factors

Out-of-whack microbes in the vagina can raise HIV risk — and now there’s evidence that the makeup of the penis microbiome matters, too. The greater the number of anaerobic bacteria tucked under the foreskin, the more likely an uncircumcised man is to become infected with the virus, researchers report July 25 in mBio.

“This mirrors what’s been seen in women, but it’s the first study of its kind in men,” says Deborah Anderson, a microbiologist and gynecologist at Boston University School of Medicine.
The data come from heterosexual Ugandan men followed for two years as part of a larger study on circumcision. Researchers swabbed the men’s penises to collect bacteria samples at the beginning of the two-year study. Then they compared the penile bacterial composition of the 46 uncircumcised men who became infected with HIV over the course of the study with that of 136 uncircumcised men who didn’t.

The total amount of penile bacteria didn’t differ, but men with higher levels of anaerobic bacteria were more likely to have contracted HIV, researchers found. Having 10 times more Prevotella, Dialister, Finegoldia and Peptoniphilus bacteria raised the risk of contracting HIV by 54 to 63 percent after controlling for other factors that might affect risk, such as condom use habits and number of sexual partners.

The results might help explain why circumcision cuts the risk of HIV, says Thomas Hope, a cell biologist at Northwestern University Feinberg School of Medicine in Chicago: Removing the flap of foreskin takes away a moist hideout for bacteria that thrive in oxygen-starved environments. But, Hope cautions, the study only draws an association between the microbiome and HIV — not necessarily a cause and effect.

It’s not clear how certain bacteria might raise HIV risk, but the new study revealed one possible clue: Men with more anaerobic penis bacteria also had higher levels of inflammatory cytokine proteins, which call immune cells to the scene.

“Specific bacteria might cause inflammatory response that would cause the immune cells to congregate in the penis, where they’re more likely to be exposed to the virus,” says study coauthor Cindy Liu, a pathologist at George Washington University in Washington, D.C. HIV targets particular immune cells, so recruiting an immune response to the penis might have an unintended consequence — a free ferry ride for the virus into the bloodstream.
Liu and colleagues hope to test that explanation more thoroughly by looking at tissue samples from circumcised foreskins, and seeing whether there’s a relationship between the penis microbiome and the kinds of immune cells found in the foreskin.

Some of these same bacteria are also linked to increased HIV risk in women, and the microbes can be swapped between partners during sex. While practicing safe sex is still the best HIV-prevention strategy, topical creams that adjust the bacterial balance on the penis might someday help lower the risk of infection, Liu says.

New spending bill mostly boosts money for science research

After some initial waffling, President Trump signed a budget bill March 23 that lays out spending details for the rest of fiscal year 2018, which goes through September. The $1.3-trillion spending deal boosts funding for nearly all science agencies, avoiding cuts the White House had proposed.

These increases stem largely from February’s budget deal, which raised caps on discretionary spending. The National Institutes of Health, which got a $3 billion bump over the 2017 level, comes out especially well, as does the Department of Energy’s Office of Science. It receives an $868 million boost, a 16 percent increase. Climate science research and programs across several agencies also avoided big cuts that the administration had proposed.
The one outlier: the Environmental Protection Agency. At about $8.1 billion, its budget remains flat at the 2017 level.

Here are a few details that stood out to us.

NIH
NIH gets an extra $414 million for Alzheimer’s disease research, along with $400 million for the BRAIN Initiative, a research project announced by President Obama in 2013 that aims to improve our understanding of the human brain.
DOE Office of Science
Trump had proposed eliminating the Advanced Research Projects Agency-Energy, which funds research into long-shot but potentially high-reward projects. But the bill allocates an additional $47 million to the agency, a resounding rejection of the administration’s request.

NASA
The Wide-Field Infrared Survey Telescope, or WFIRST, is a proposed mission to study, in part, planets orbiting stars outside the solar system. It was recommended by the most recent decadal survey for astrophysics and remains one of NASA’s top astrophysics priorities after the James Webb Space Telescope. Trump has proposed canceling WFIRST, but the spending package includes $150 million for the telescope. Four earth science programs that Trump had targeted for elimination were also funded.

CDC
The agreement includes wording clarifying that the Centers for Disease Control and Prevention isn’t barred from studying gun violence under a 1996 amendment. The CDC has shied away from such research since that time. On Twitter, some celebrated the news, but others hailed it as a partial victory. Megan Ranney, an emergency physician and researcher at Brown University in Providence, R.I., who studies firearm injuries, tweeted the “announcement changes nothing. The issue has been, and continues to be, lack of appropriations for research.”

EPA
The agency’s overall budget remains flat as do projects with EPA’s Office of Science & Technology. Although not research related, the agency’s regulatory programs are cut by $23.5 million. The bill includes wording that prohibits the regulation of lead content in ammunition and fishing tackle and exempting livestock producers from EPA greenhouse gas regulations.

USGS
The bill includes $23 million for ShakeAlert, an earthquake early warning system on the West Coast that could be rolled out as early as October, another project that had been facing elimination. All eight of the U.S. Geological Survey’s climate science centers are funded in the agreement. The administration had proposed cutting their numbers in half, to four.

Some frogs may be bouncing back after killer chytrid fungus

It’s tough to be a frog once a killer skin fungus moves in. But, in Panama, the amphibians might be fighting back, researchers propose.

More than a decade ago, an amphibian-killing chytrid fungus nicknamed Bd swept through the country. Now some frog species that had nearly vanished from three regions are growing easier to spot again. But tests of the pathogen find no signs that it is weakening, says disease ecologist Jamie Voyles at the University of Nevada, Reno. With the fungus as dangerous as ever, frogs becoming resistant to the pathogen might be enabling the recovery, Voyles and her colleagues report in the March 30 Science.
Despite any glimmer of hope, it’s too early to celebrate frog recovery, protests ecologist Karen Lips at the University of Maryland in College Park. She doesn’t doubt that researchers have found frogs in the devastated regions, but wants more rigorous monitoring before talking population trends.

The three areas in the study have special resonance. They’re where Lips and other scientists set up a disaster watch as they realized that Bd, short for Batrachochytrium dendrobatidis, was sweeping through Central America, killing many amphibians in its path. As the deadly wave approached, the researchers collected data and living animals in the hope they would help in before-and-after studies. The fungus attacked Lips’ site, El Copé, in 2004 and the other two sites in 2006 and 2007.

Voyles was working at El Copé as a graduate student when Bd arrived. She remembers the abundance of sick and dying animals, and the task of collecting the dead. “That was shocking, really — there’s just no other word for it.”

Using archived, frozen samples of the fungus from those sites, Voyles and colleagues present the first comparison of Bd as it was in 2004 versus in 2012 to 2013, when amphibian communities showed signs of recovering. At first, Voyles suspected that the pathogen was growing less dangerous. Bd attacks a wide range of hosts but evolutionarily speaking, pathogens don’t persist if they drive too many of their hosts extinct.
A waning fungal menace could have explained how nine frog species that had almost disappeared in the area were now easier to spot. But the pathogen appears as lethal as ever, she and her colleagues report. Compared with the older versions, the more recent fungus samples grew and reproduced at about the same speeds, and inhibited immune cells at about the same rates. All fungi killed the test frogs of two species.

“That’s an important result,” says evolutionary ecologist James Collins of Arizona State University in Tempe. Biologists who study the interplay of pathogen and host often ask how the two change in relation to one another over time. But having real data on the relationship is much rarer. Also important, he says, is recognizing that “many species at the Panama sites are still missing, so wholesale recovery isn’t occurring.”
To explain the encouraging cases, the researchers propose that in some species, frog skin secretions may be getting better at repelling the fungus. For wild animals of six amphibian species, secretions from pre-disease days were worse at inhibiting fungal growth in a lab test than secretions from the same species at sites that the fungus had hit. In another test, secretions from wild variable harlequin frogs (Atelopus varius) were about eight times as effective at inhibiting the fungus as were those from zoo animals descended from frogs collected before Bd reached their site.

Of the many amphibian populations that Bd savaged around the world (SN: 3/5/16, p. 14), a few have bounced back in numbers. Sierra Nevada yellow-legged frogs now abound again in the California mountains, ecologist Vance Vredenburg of San Francisco State University points out. Yet these animals are descendants of a worryingly tiny percentage of the original, diverse population. Despite rebounds, attacks by deadly fungi are still “a really big deal,” he says.

With the launch of TESS, NASA will boost its search for exoplanets

NASA is stepping up its search for planets outside our solar system. Its next exoplanet hunting telescope, the Transiting Exoplanet Survey Satellite (TESS), is due to launch from Cape Canaveral on the evening of April 16.

Following the Kepler space telescope’s discovery of more than 5,000 possible exoplanets since 2009, TESS will continue the galactic census — flagging more planetary candidates for further study.

Astronomers expect TESS to find about 20,000 planets in its first two years in operation, focusing on nearby, bright stars that will be easy for other telescopes to investigate later. About 500 of those expected exoplanets would be less than twice the size of Earth — and therefore may be good places to look for life.
The TESS mission is “a whole new opening for exoplanet studies,” MIT astronomer Sara Seager, TESS’ deputy science director, said during a news conference describing the upcoming launch.
TESS will be the first NASA science mission launched on the SpaceX Falcon 9 rocket. Once in orbit, the spacecraft will trace an unusual, elliptical path between Earth and the moon that will enable it to observe at least 85 percent of the sky — 350 times as much sky as Kepler saw.
Most of the planets found by Kepler orbit stars 1,000 light-years away or farther. TESS will focus on 200,000 stars that are a few hundred light-years away at most, and shine between 30 to 100 times brighter on average than Kepler’s.

The brighter the star, the easier it is to determine its planet’s characteristics, such as its mass and whether it has an atmosphere, Seager says. “Photons are our currency — the more, the better,” she says.

That follow-up will help TESS avoid some of Kepler’s pitfalls. Because Kepler’s stars were so far and so dim, some of its planet candidates were confirmed as actual planets only by statistics rather than by other telescopes. And not all those confirmations may stick. A recent paper posted at arXiv.org showed that Kepler 452b, an Earth-sized planet that orbits a sunlike star at the same distance Earth orbits the sun, may be a mirage (SN: 8/22/15, p. 16). Many of TESS’ planets won’t face the same uncertainty.
But the way TESS will search for exoplanets is the same as Kepler: The satellite will watch stars for signs of dimming, which can indicate that a planet is transiting, or crossing in front of, the star. Measuring how much starlight is blocked can tell astronomers the size of the planet.

Once TESS finds a planet, astronomers will need more information to understand its qualities, such as whether it’s rocky or gassy (SN Online: 6/19/17). For that, other telescopes will follow up. Ground-based telescopes will measure the gravitational tug of a planet on its host star to learn the planet’s density, which is a clue to its composition. Astronomers plan to measure masses for at least 50 TESS planets that are smaller than Neptune in the hopes that many of them will have rocky, and therefore potentially habitable, surfaces.
NASA’s James Webb Space Telescope, now scheduled to launch in 2020, will then check some of those planets for signs of life (SN: 4/30/16, p. 32).

“This is one of the major questions that TESS is intended to answer: Where will we be pointing Webb?” said the mission’s principal investigator, MIT astronomer George Ricker, at the press conference. Webb will peer at the starlight filtering through planetary atmospheres to try to detect molecules that could be produced by something living on the surface.

It will take a few months for TESS to swing into its regular orbit before it begins collecting data. At that point, it will be able to use the moon’s gravity to stabilize itself for decades in orbit without using extra fuel. The mission is set to last two years, but could continue taking data almost indefinitely.

“TESS is not going to be limited by any expendable or other aspects,” Ricker said. “It will be basically limited by how long NASA has the patience to fund the mission.”

These hummingbirds aim their singing tail feathers to wow mates

There’s more subtlety than humans have realized in dropping out of the sky so fast your tail feathers sing.

Male Costa’s hummingbirds in western North America are masters of the tail-screaming courtship plunge. Acoustic cameras recorded these repeated stunts and revealed that, as the male whooshes down, he twists half of his tail sideways, says ornithologist Christopher J. Clark of the University of California, Riverside. That twist aims the prolonged feather whistle toward the female he’s swooping by, Clark and his colleague Emily Mistick of the University of British Colombia in Vancouver report April 12 in Current Biology.
The recordings, which use microphone arrays to localize a sound on video, shed light on another quirk of Calypte costae’s performance. While male hummingbirds of other species swoop over the female during courtship dives, the shimmery purple-faced Costa’s zoom by on the side.

Extra distance in the side flyby minimizes the Doppler effect on the feather sound. That effect may be familiar from the EEEEEEooooo of an ambulance’s siren that sounds high-pitched as the vehicle approaches and then seems to lower after it passes. Masking the Doppler effect could make it harder for a female to pick out the fastest divers, although researchers haven’t shown how these females perceive speed or whether it matters much to them.

The diving sounds, made from the flutter of the outermost tail feather, also seem similar to the males’ vocalizations, Clark says. So he wonders if females find something in both especially seductive.

Want to build a dragon? Science is here for you

No fantasy world is complete without a fire-breathing dragon. SpaceX founder Elon Musk even wants to make a cyborg version a reality, or so he tweeted April 25. But if someone was going to make a dragon happen, how would it get its flame? Nature, it seems, has all the parts a dragon needs to set the world on fire, no flamethrower required. The creature just needs a few chemicals, some microbes — and maybe tips from a tiny desert fish.

Fire has three basic needs: something to ignite the blaze, fuel to keep it burning and oxygen, which interacts with the fuel as it burns. That last ingredient is the easiest to find. Oxygen makes up 21 percent of Earth’s atmosphere. The bigger challenges are sparking and fueling the flame.
All it takes to strike a spark is flint and steel, notes Frank van Breukelen, a biologist at the University of Nevada, Las Vegas. If a dragon had an organ like a bird’s gizzard, it could store swallowed rocks. In birds, those rocks help get around a lack of teeth, allowing them to break down tough foods. Inside a dragon, swallowed flint might rub against some steel, sparking a flame. “Maybe what you have is sort of scales that are flintlike and click together,” van Breukelen says. If the spark was close enough to a very sensitive fuel, that might be enough to ignite it.
But some chemicals don’t need that initial spark. Pyrophoric molecules burst into flame the instant they contact air. Consider the element iridium, says Raychelle Burks, a chemist at St. Edwards University in Austin, Texas. It burns different colors when it becomes part of various molecules. One of them burns a warm orange or red. Another burns a violet-blue. (That’s one way to get the blue flame of the zombie ice dragon in George R.R. Martin’s Game of Thrones series.)
Unfortunately, iridium isn’t common, especially in biology. “There are a lot of cool elements on the periodic table, but [living things] only use a few,” Burks explains.

There are other pyrophoric chemicals that a dragon might find a little closer to home, notes Matthew Hartings, a chemist at American University in Washington, D.C. Assume that dragons like caves, he begins. “If you’re living amongst a bunch of rocks, you’ll have access to a high amount of iron.”

Iron can react with another chemical, hydrogen sulfide. This is a flammable gas that smells like rotten eggs, and gives Uranus its new signature scent. It is found in crude oil. When hydrogen sulfide and iron get together — in a rusty oil pipe, for example — the result is iron sulfide. Combine it with air and you’ve got an explosive mix. Iron sulfide is sometimes the culprit when gas pipelines or tanks blow up.

Another explosive option comes from Anne McCaffrey’s series The Dragonriders of Pern. McCaffrey describes her dragons chewing on rocks containing phosphine, a chemical made of one phosphorus atom and three hydrogen atoms. In gas form, phosphine is extremely flammable and explodes on contact with oxygen. It’s also very toxic: Just seven drops of its liquid form can kill someone.

Burning burps
Fictional dragons often spout flaming gas. But a gas would present problems, Hartings says. Gas, he notes, expands to fill available space. To keep it contained, a dragon would have to keep that gas under pressure.

Chemicals like phosphine, therefore, aren’t the perfect dragon-fire solution, Hartings says. The boiling point for phosphine is -84° Celsius (-120° Fahrenheit). At room (or dragon breath) temperature, it’s a gas. “You’d have to really compress it,” he says, to make it a liquid that a dragon could store and use.

Also, Hartings notes, gases are difficult to control. If a dragon blew some fiery gas into the wind, the flames might wash back on the creature and singe its face. “You have a much better chance of controlling your flame spray if you’re pushing liquid rather than a gas,” he explains.

A liquid also would help avoid self-burning, Hartings notes. The liquid with its flammable gas would ignite as soon as it hit air. Speed is key. “As long as you are shooting it out fast enough, [the] particles don’t hit the air until they are far enough away from your face,” he notes.

A combination of liquid and gas might work even better, Burks suggests. In an aerosol spray, tiny liquid droplets are suspended in a pressurized gas, which spurts out when it is released. If a dragon were to shoot an aerosol spray, it could look like a gas, with some of the properties of a liquid. “In a fine aerosol spray it would look like the dragon is spraying fire,” Burks notes. The aerosol would spread out, she says, “and the minute it hits air — kaboom!”

Something fiery, something fishy
Plenty of liquids in nature will burn. Living things already produce two of these that might work for a dragon: ethanol and methanol. Both are alcohols often burned as fuels.

“Certainly, we know that yeast makes ethanol,” Hartings says. These single-celled fungi transform sugars into alcohol. That’s why they’re used to brew beer and make other alcoholic beverages. A dragon with a bellyful of yeast is not as silly as it might appear. Yeast are part of the microbial community that lives on and in people and other animals.

Methanol first requires methane. Ruminants — including cows, goats, giraffes and deer — make methane during digestion. Certain bacteria can turn methane into methanol, Hartings notes. A dragon that got enough fiber in its diet to make methane could pass that gas on to its bacterial buddies, who would convert it into methanol.
But those bacterial coworkers might not even be needed. The Devil’s Hole pupfish doesn’t bother with them. The fish are a tiny, incredibly rare species found in Devil’s Hole — a single, naturally heated pool in Nevada. This fish can whip up its own whiskey in a pinch, van Breukelen and his colleagues have shown.
Temperatures in Devil’s Hole reach 33 °C (91 °F). There is very little oxygen in the water to start with. When it gets hot, the oxygen levels drop even lower — too low for the fish to breathe. So pupfish stop using oxygen. Instead, they produce energy anaerobically, no oxygen required. In the process, their bodies make ethanol.

The fish produce 7.3 times more ethanol than fish living in cooler water, van Bruekelen and his colleagues reported in 2015 in the Journal of Experimental Biology.

A dragon might be able to produce ethanol under similar circumstances. However, van Breukelen says, it’s not quite so simple. “I don’t think there’s a way to keep ethanol. I don’t think you could store it,” he says. The reason: It seeps through everything. Ethanol, he explains “goes right through membranes.” Those include the membranes that surround cells and organs. When pupfish produce ethanol, the chemical ends up throughout the fish. It would not pool as a concentrate in some pouch or organ. So any dragon that made ethanol would have trouble storing enough to get a decent flame going.

The pupfish won’t be setting the world on fire — nor will dragons. One is a tiny fish, and the other isn’t real. But if Musk wants to figure out how to make his cyborg dragon light up the world, he doesn’t need to look to fossil fuels. Nature has him covered.

New genetic details may help roses come up smelling like, well, roses

There’s new hope for making modern roses smell sweeter than the florist paper they’re wrapped in.

By decoding the genetics of an heirloom variety, a fragrant pink China rose called “Old Blush,” an international team of researchers has uncovered some new targets to tweak. That roster of genes plus an analysis of scent revealed at least 22 previously uncharacterized biochemical steps the plants can use to make terpene compounds, which help give roses their perfume, researchers report April 30 in Nature Ge­­­netics.
Modern roses have had a crazy history of blending genes from eight to 20 species, so decoding the DNA hodgepodge has been difficult. Rose breeders have opted for “showy plants,” says molecular geneticist Mohammed Bendahmane of École Normale Supérieure in Lyon, France. In the process, fragrances dwindled, and efforts to build them back in have not been fabulous.

The new paper focused on Rosa chinensis, one of the major contributors to modern hybrids, now mixed with European and Middle Eastern lineages of roses. The study’s new details clarify that some of the rose’s genes work in opposition to one other, with some turning on to brew a scent component while others shut down manufacture of anthocyanin pigments needed for rosy petals. Knowing this could help modern rose breeders resolve a trade-off that has sacrificed scent for color.

Examining one of the early hybrids, called La France, also suggests the China rose contributed the genes for the prized trait of prolonged blooming. And the genetic survey turned up genes that might inspire ways to make the plants more water efficient and last longer in a vase.

Last year’s solar eclipse set off a wave in the upper atmosphere

It was the eclipse felt ‘round the world. The August 21, 2017, total solar eclipse that crossed the United States launched a wave in the upper atmosphere that was detected nearly an hour later from Brazil (SN Online: 8/11/17).

“The eclipse itself is a local phenomenon, but our study shows that it had effects around the world,” says space scientist Brian Harding of the University of Illinois at Urbana-Champaign.

Harding watched the eclipse from St. Louis. But he and his colleagues activated a probe near São João do Cariri, Brazil, to observe uncharged particles 250 kilometers high in a part of the atmosphere called the thermosphere.
The probe recorded a fast-moving wave in the thermosphere go by half an hour after sunset in São João do Cariri and 55 minutes after the end of the total eclipse, the team reported April 24 in Geophysical Research Letters. The wave is produced by the motion of the moon’s shadow, which cooled the atmosphere below it. That cold spot then acted like a sink, sucking in the warmer air ahead of it and causing a ripple in the atmosphere as the cold spot moved across the globe.

Previous eclipses also have launched waves at similar altitudes in the ionosphere, the charged plasma of the atmosphere, which overlaps with the electrically neutral thermosphere (SN Online: 8/13/17). This is the first time that scientists have observed a wave in the uncharged part of the atmosphere. Neutral particles are 100 to 1,000 times denser than plasma in the atmosphere, and it’s important to know how they behave too, Harding says.

In honor of his centennial, the Top 10 Feynman quotations

As Richard Feynman once said, “a man cannot live beyond the grave,” and so surely Feynman could not speak from the grave, either. Except that actually, he did.

For years after his death in 1988, books appeared with collections of Feynman’s articles, talks and other miscellaneous writings. Together with his two autobiographical books and his famous lectures on physics, those works offer an enormous corpus of wisdom, advice, opinion and insight into nature, science, life and society. His words are widely quoted, and in fact his most noteworthy quotations fill up a fat book edited by his daughter Michelle, The Quotable Feynman (Princeton University Press, 2015).
You could read that whole book if you like, of course. But if you’re short on time, you could just peruse the Top 10 Feynman Quotes below, selected from his works to commemorate the 100th anniversary of Feynman’s birth on May 11. (At least they’re my favorite 10. He might have ranked them differently.)

  1. “If, in some cataclysm, all of scientific knowledge were to be destroyed, and only one sentence passed on to the next generations of creatures, what statement would contain the most information in the fewest words? I believe it is the atomic hypothesis … that all things are made of atoms — little particles that move around in perpetual motion, attracting each other when they are a little distance apart, but repelling upon being squeezed into one another.”
    From the famous Feynman Lectures on Physics, this statement exemplifies Feynman’s gift for distilling the essence from complicated science and expressing it colloquially. His words really ought to be inscribed somewhere in a permanent form, just in case.
  2. “There is nothing that living things do that cannot be understood from the point of view that they are made of atoms acting according to the laws of physics.”
    A further expression of the importance of atoms from the opening pages of Feynman’s lectures. If anyone still disagrees with this sentiment, they should watch Westworld.
  3. “For a successful technology, reality must take precedence over public relations, for nature cannot be fooled.”
    This statement was Feynman’s succinct way of telling NASA to clean up its act after the explosion of the space shuttle Challenger in 1986.
  4. “From my knowledge of the world that I see around me, I think that it is much more likely that the reports of flying saucers are the results of the known irrational characteristics of terrestrial intelligence than of the unknown rational efforts of extra-terrestrial intelligence.”
    In a set of lectures compiled in book form as The Character of Physical Law, Feynman discussed scientific exploration as not seeking certainty, or proving some things impossible, but identifying what is probable. Flying saucers are possible, but are not therefore likely to exist; they are much more probably figments of overactive human imaginations (or deliberate attempts at deception).
  5. “Most likely anything that you think of that is possible isn’t true. In fact that’s a general principle in physics theories: no matter what a guy thinks of, it’s almost always false.”
    From another series of lectures, compiled as The Meaning of It All, in which Feynman expanded on the probabilistic nature of scientific knowledge. Many more things are possible than reality can accommodate; statistically, therefore, most possibilities are actually not true. That explains why so much that so many people say is so wrong.
  6. “What is necessary ‘for the very existence of science,’ and what the characteristics of nature are, are not to be determined by pompous preconditions, they are determined always by the material with which we work, by nature herself.”
    Also from The Character of Physical Law, this Feynman sentiment should remind scientists blinded by philosophical predispositions that defining “science” is not up to people, whether lexicographers or philosophers. Nature writes the rules. Science is the process of finding out what its own rules need to be to decipher the rules for the universe that nature has written.
  7. “There’s plenty of room at the bottom.”
    This simple statement was the title of a talk Feynman delivered in 1959, widely regarded today as the original inspiration for the origin of nanoscience and nanotechnology. Feynman recognized that miniaturization in recording information was limited only by the size of atoms, and he even imagined that atoms could someday be manipulated individually. And they have been.
  8. “Nature isn’t classical, dammit, and if you want to make a simulation of nature, you’d better make it quantum mechanical.”
    Feynman wasn’t the first to consider the idea of a quantum computer, but his words (from a 1981 talk, published in 1982) inspired some physicists to take the idea seriously. Feynman had no idea how to actually build a quantum computer, and serious work on real designs didn’t begin until the late 1990s. Today’s primitive versions of quantum computers can solve some simple problems and may soon be able to outperform standard computers on some types of problems, many experts believe. And perhaps such computers will, in fact, be able to simulate how nature works. (By the way, this statement is misquoted in The Quotable Feynman. As Feynman would have advised, always check things out for yourself.)
  9. “I think I can safely say that nobody understands quantum mechanics.”
    As Feynman said in The Character of Physical Law, many people understand other sophisticated physical theories, including Einstein’s relativity. But quantum mechanics resists an equivalent depth of understanding. Some disagree, proclaiming that they understand quantum mechanics perfectly well. But their understanding disagrees with the supposed understanding of others, equally knowledgeable. Perhaps Feynman’s sentiment might better be expressed by saying that anyone who claims to understand quantum mechanics, doesn’t.
  10. “The first principle is that you must not fool yourself — and you are the easiest person to fool.”
    The best Feynman quote of all (from a 1974 address), and the best advice to scientists and anybody else who seeks the truth about the world. The truth may not be what you’d like it to be, or what would be best for you, or what your preconceived philosophy tells you that it is. Unless you recognize how easily you can be fooled, you will be.