China on Monday released the first Mars global images obtained from its first Mars exploration mission, providing an improved quality base map for scientific and exploration tasks on the Red Planet, the Global Times learned from the China National Space Administration (CNSA) at the opening ceremony of this year's Space Day of China.
The color images, jointly issued by the CNSA and the Chinese Academy of Sciences (CAS), included orthographic, Robinson, Mercator and azimuthal projections of the eastern and western hemispheres of Mars with a spatial resolution of 76 meters.
The image maps will provide an improved quality base map for Mars exploration projects and scientific research, the CNSA said, and data obtained by the Tianwen mission will make key contributions to humanity's in-depth knowledge of the planet.
The medium-resolution camera onboard Tianwen-1 took 284 orbital remote sensing images from November 2021 to July 2022, so as to achieve global coverage of the Martian surface. Some 14,757 images were acquired by the ground-based application system, which were then processed to obtain the global color image map of Mars.
China's panoramic map of Mars is one of the most advanced in the field that is open to the public, experts noted, and it means that China is willing to share cutting-edge technology and information with its peers.
"This year's China Space Day underscores our willingness to share information with the world, showing that China's space achievements are entirely for the development of human scientific and technological progress. It also suggests our growing confidence in this field," Song Zhongping, a space analyst and TV commentator, told the Global Times on Monday.
"Technology has no borders, but the US has been constantly putting up shields and fences to block others from its technology, as well as engaging in technological monopolies, information hegemony and a Cold War in space," he said.
At the opening ceremony on Monday, the CNSA also disclosed that 22 sites on Mars have been given Chinese names.
China's research teams have identified a large number of geographical entities near the landing site of Tianwen through high-resolution images, and the International Astronomical Union has named 22 of them after villages in China with historical and cultural significance and a population of less than 100,000.
In this way, China's presence is permanently engraved on Mars' surface.
Tianwen-1, China's first Mars mission probe, embarked on its journey on July 23, 2020, and after 202 days of travel, it began to orbit Mars. On May 15, 2021, the land rover Zhurong landed in a designated spot on the Martian surface and started its trek. It completed its 90-Martian-day scientific exploration task and kept working for another 268 Martian days, and has remained in hibernation mode since.
As of June 29, 2022, the Mars orbiter had carried out global remote sensing for more than 1,000 days, and it is still carrying on its mission in fine condition.
China's first Mars mission, which orbits Mars, land and rove in one go, was completed successfully.
The 13 payloads carried by the mission have accumulated 1,800 gigabytes of scientific data and formed standard data products.
Over the past two years, Tianwen-1 has obtained first-hand detection data and achieved notable scientific research results, which analysts said would be continued with further multi-dimensional exploration missions being carried out.
In May 2022, a research team from the CAS detected water-bearing minerals on Mars by analyzing data collected by the Zhurong rover, marking a world first that water-bearing minerals on the planet were detected by a short-wave infrared spectrometer on a Mars rover. The findings have been published in detail in the journal Science.
Another major discovery by the Chinese Mars rover came when scientists used a ground-penetrating radar on Zhurong to find possible evidence of floods on the Red Planet billions of years ago. Though no direct evidence for liquid water was found in the shallow subsurface, the study lends weight to the theory that the rover's landing area - the Utopia Planitia - once hosted an ancient ocean, researchers from the CAS and Peking University said in a Nature paper published in September 2022.
China launched its largest solid propellant rocket Lijian-1 on Wednesday, successfully sending 26 satellites into preset orbit and setting the country's new record for launching multiple satellites in one go. The satellites will mainly provide commercial remote sensing information services.
The Wednesday launch marks the second flight of Lijian-1, indicating the maturity of the solid propellant rocket's technology and the continuous improvement of its reliability, which can further boost the commercialization of China's launch vehicles.
In an exclusive interview with the Global Times, chief engineer assistant on Lijian-1 Shi Xiaoning said he was quite confident about the rocket as its reliability has been verified. But he was still concerned about the separation of satellites from the rocket.
"This time, there were more satellites to send and we not only needed to ensure that each of them could be successfully separated, but also ensure the accuracy of the satellite's orbit insertion, which was quite challenging," Shi said. "Therefore, we closely monitored data for each satellite separation, but in the end we accurately delivered each satellite to the designated orbit."
Lijian-1 made its maiden flight on July 27, 2022, successfully sending six satellites into their preset orbits. According to its developer, the Chinese Academy of Sciences (CAS), the 2.65-meter-diameter and 30-meter-long new rocket is the largest of its kind in China.
It has achieved breakthroughs in six key technologies and utilized 13 domestic technologies for the first time, enriching China's spectrum of solid carrier rocket launch capabilities and making significant contributions to the technological transformation of China's carrier rocket industry.
Lijian-1 is a four-stage launch vehicle weighing 135 tons at launch with a thrust of 200 tons. It is capable of sending payloads of 1,500 kilograms into 500-kilometer Sun-synchronous orbits (SSO). Prior to that, the capacity of Chinese commercial space rockets in SSO was below 1,000 kilograms.
For the next step, the rocket developer Guangzhou Zhongke Aerospace Exploration Technology Co (CAS Space) will continue to enrich the spectrum of China's solid propellant launch vehicles. In addition to building a sea launch platform for Lijian-1, a new solid rocket with a diameter of 3.5 meters is also under development, the Global Times has learned.
The future of disease tracking is going down the drain — literally. Flushed with success over detecting coronavirus in wastewater, and even specific variants of SARS-CoV-2, the virus that causes COVID-19, researchers are now eyeing our collective poop to monitor a wide variety of health threats.
Before the pandemic, wastewater surveillance was a smaller field, primarily focused on testing for drugs or mapping microbial ecosystems. But these researchers were tracking specific health threats in specific places — opioids in parts of Arizona, polio in Israel — and hadn’t quite realized the potential for national or global public health. Then COVID-19 hit.
The pandemic triggered an “incredible acceleration” of wastewater science, says Adam Gushgari, an environmental engineer who before 2020 worked on testing wastewater for opioids. He now develops a range of wastewater surveillance projects for Eurofins Scientific, a global laboratory testing and research company headquartered in Luxembourg.
A subfield that was once a few handfuls of specialists has grown into more than enough scientists to pack a stadium, he says. And they come from a wide variety of fields — environmental science, analytical chemistry, microbiology, epidemiology and more — all collaborating to track the coronavirus, interpret the data and communicate results to the public. With other methods of monitoring COVID-19 on the decline, wastewater surveillance has become one of health experts’ primary sources for spotting new surges.
Hundreds of wastewater treatment plants across the United States are now part of COVID-19 testing programs, sending their data to the National Wastewater Surveillance System, or NWSS, a monitoring program launched in fall 2020 by the U.S. Centers for Disease Control and Prevention. Hundreds more such testing programs have launched globally, as tracked by the COVIDPoops19 dashboard run by researchers at the University of California, Merced.
In the last year, wastewater scientists have started to consider what else could be tracked through this new infrastructure. They’re looking at seasonal diseases like the flu, recently emerging diseases like bird flu and mpox, formerly called monkeypox, as well as drug-resistant pathogens like the fungus Candida auris. The scientists are even considering how to identify entirely new threats.
Wastewater surveillance will have health impacts “far broader than COVID,” predicts Amy Kirby, a health scientist at the CDC who leads NWSS.
But there are challenges getting from promise to possible. So far, such sewage surveillance has been mostly a proof of concept, confirming data from other tracking systems. Experts are still determining how data from our poop can actually inform policy; that’s true even for COVID-19, now the poster child for this monitoring. And they face public officials wary of its value and questions over whether, now that COVID-19 health emergencies have ended, the pipeline of funding will be cut off.
This monitoring will hopefully become “one of the technologies that really evolves post-pandemic to be here to stay,” says Mariana Matus, cofounder of Biobot Analytics, a company based in Cambridge, Mass., that has tested sewage for the CDC and many other health agencies. But for that to happen, the technology needs continued buy-in from governments, research institutions and the public, Matus and other scientists say.
How wastewater testing works Wastewater-based epidemiology has a long history, tracing back at least to physician John Snow’s 1850s observations that cholera outbreaks in London were connected to contaminated water. In the 1920s and ’30s, scientists began to take samples from sewage and study them in the lab, learning to isolate specific pathogens that cause disease. These early researchers focused on diseases that spread through contaminated water, such as polio and typhoid.
Today, automated machines typically retrieve sewage samples. The machines used to collect waste beneath maintenance hole covers are “like R2-D2 in terms of size” or smaller, says Erin Driver, an environmental engineer at Arizona State University in Tempe who works on collection methods.
Driver can plug this machine, or a larger version used for sampling at wastewater treatment plants, into a water pipe and program it to pull a small amount of sewage into an empty bottle at regular intervals, say, once an hour for 24 hours. She and colleagues are developing smaller versions of the automated sampler that could be better suited for more targeted sampling.
What happens in the lab to that bottle of waste depends on what scientists are testing for. To test for opioids and other chemicals, scientists might filter large particles out of the sample with a vacuum system, extract the specific chemicals that they want to test, then run the results through a spectrometer, an instrument that measures chemical concentrations by analyzing the light the chemicals give off.
To determine levels of SARS-CoV-2 or another virus, a scientist might separate liquid waste from solid waste with a centrifuge, isolate viral genetic material, and then test the results with a PCR machine, similar to testing someone’s nose swab. Or, if scientists want to know which SARS-CoV-2 variants are present, they can put the material through a machine that identifies a variety of genetic sequences.
Would the coronavirus even show up in waste? In the panicked early days of the pandemic, an urgent basic question loomed. “Will this even work?” remembers Marlene Wolfe, an environmental microbiologist at Emory University in Atlanta. While polio is spread through fecal matter, there were early hints that the coronavirus mostly spreads through the air; scientists initially weren’t even sure that it would show up in sewage.
On the same day in 2020 that the San Francisco Bay Area went on lockdown, Wolfe and colleagues at Stanford University, where she was based at the time, got a grant to find out. The team was soon spending hours driving around the Bay Area to collect sewage samples, “navigating lockdown rules” and negotiating special permissions to use lab space, she says.
“We were anxiously waiting to see if our first samples would show a positive result for SARS-CoV-2,” Wolfe says.
Not only did the sewage samples test positive, Wolfe and her colleagues found that coronavirus levels in the Bay Area’s wastewater followed the same trends as reported cases, the team reported in December 2020 in Environmental Science & Technology. When case counts went up, more virus appeared in the sewage, and vice versa. Early projects in other parts of the country showed similar results. More than three years later, data on reported cases have become much less reliable. Fewer people are seeking out lab-based PCR tests in favor of easier-to-access at-home tests — with results often not reported. Wastewater trends have become the best proxy to provide early warnings of potential new COVID-19 surges, such as the increased spread this summer, to health officials and the public alike.
Opening the tracking floodgates In summer 2022, wastewater tracking got a new chance to prove itself. Mpox was rapidly spreading globally, including in the United States. But tests were limited, and the disease, which was spreading primarily through intimate contact between men, quickly drew social stigma, leading some people to hesitate in seeking medical care.
Within a few weeks of the start of the U.S. outbreak, Wolfe and her colleagues, as well as research teams at Biobot and other companies, had developed tests to identify mpox in sewage.
Just as scientists had seen with COVID-19, mpox trends in wastewater matched trends in official case numbers. In California, wastewater results even suggested that the disease may have spread farther than data from doctors’ offices suggested, Wolfe and collaborators reported in February in the New England Journal of Medicine.
Like COVID-19, mpox doesn’t transmit through the water, but sewage testing still picked up the virus. The early results from that summer outbreak convinced some health officials that wastewater technology could be used for many diseases, no matter how they spread, Matus says. Scientists are starting to find more and more infectious diseases that can be tracked in sewage. “Honestly, everything that we’ve tried so far has worked,” says Wolfe, who is now a principal investigator of WastewaterSCAN, a national sewage testing project led by researchers at Stanford and Emory. The project team currently tests samples for six different viruses and is working on other tests that it can send out to the more than 150 sites in its monitoring network.
Through an informal literature review of pathogens important for public health, scientists at Biobot found that previous research had identified 76 out of 80 of them in wastewater, stool or urine, suggesting that those pathogens could be monitored through sewage. The list ranges from the chicken pox virus to the microbes that cause sexually transmitted diseases like chlamydia to the tickborne bacteria that cause Lyme disease.
Finding focus With this much opportunity, the question on many researchers’ minds is not, “What can we test for?” but “What should we test for?”
In January, a report put out by the National Academies of Sciences, Engineering and Medicine came up with three criteria. The pathogen should threaten public health. It should be detectable in wastewater. And it should generate data that public health agencies can use to protect their communities.
Given all the threats and hints of what can be found in wastewater, the first two criteria don’t narrow the field too much. So for now, researchers are taking cues from state and local public health officials on which pathogens to prioritize.
Biobot is working on tests for common diseases like the flu, RSV, hepatitis C and gonorrhea. And the CDC has its eye on some of the same common pathogens, as well as strategies for tracking antimicrobial resistance, a threat that has increased during the pandemic as health systems have been under strain.
Even if they choose the perfect targets, though, researchers also have to figure out how to generate useful data. For now, that’s a sticking point.
How to use the data Tracking pathogens is one thing. But determining how the results correspond to actual numbers of sick people is another, even in the case of COVID-19, where researchers now have years of detailed data. As a result, many public health officials aren’t yet ready to make policy decisions based on poop data.
In New York City over the last three years, for example, the local government has poured more than $1 million into testing for COVID-19, mpox and polio in sewage from the city’s water treatment plants. But the city’s health department hasn’t been using the resulting data to inform local COVID-19 safety measures, so it’s unclear what’s being done with the data. Health officials are used to one swab per person, says Rachel Poretsky, a microbiologist at the University of Illinois Chicago. She also heads wastewater monitoring for the city of Chicago and the state of Illinois.
Public health training relies on identifying individual sick people and tracing how they became ill. But in wastewater surveillance, one data point could represent thousands of sick people — and the data come from the environment, rather than from hospitals and health clinics. What to do next when positive results turn up isn’t as obvious.
Numbers collected from the health care system always represent patients, so a spike indicates a surge in cases. In the case of sewage data, however, environmental factors like weather, local industries and the coming and going of tourists also can create “weird outliers” that resist easy interpretation, Poretsky says. For instance, a massive rainstorm might dilute samples, or chemical runoff from a factory might interfere with a research team’s analytical methods.
Data interpretation only gets more complicated when scientists begin testing wastewater for an increasing number of health threats. Every pathogen’s data need to be interpreted differently.
With coronavirus data, for example, wastewater tests consistently come back positive, so interpreting the data is all about looking for trends: Are viral concentrations going up or down? How does the amount of virus present compare with the past? A spike in a particular location might signal a surge in the community that hasn’t yet been picked up by the health care system. The community might respond by boosting health resources, such as opening vaccine clinics, handing out free masks and at-home tests, or adding staff to local hospital emergency departments.
Mpox, on the other hand, has infected far fewer people, and positive tests have been rare after last summer’s outbreaks ended. Now, researchers are simply watching to see whether the virus is present or absent in a given sewershed.
“It’s more about having an early warning,” Matus says. If a sewershed suddenly tests positive for mpox after negative results for the last few months, health officials might alert local doctors and community organizations to look out for anyone with symptoms, aiming to identify any cases and prevent a potential outbreak.
Another complicated pathogen is C. auris, a fungus that has developed resistance to common drugs. It can spread rapidly in health care settings — and be detected in sewage. Researchers from Utah and Nevada reported in February in Emerging Infectious Diseases that it was possible to track C. auris in the sewage from areas experiencing outbreaks.
If hospitals or health officials could identify the presence of this fungus early, that information could guide public health actions to curb outbreaks, says Alessandro Rossi, a microbiologist at the Utah Public Health Laboratory in Salt Lake City. But interpreting the warnings isn’t as clear-cut for C. auris as for viruses.
The fungus can grow in sewage after it leaves health care facilities, Rossi says. The pathogen has “the potential to replicate, form biofilms and colonize a sewershed.” In other words, C. auris can create its own data interference, potentially making wastewater results seem worse than they really are. Moving wastewater into the future Most current testing programs are reactive. By looking at health threats one at a time using specific PCR tests, the programs mostly confirm that pathogens we already are worrying about are getting people sick.
But some scientists, like Wim Meijer, envision a future in which wastewater monitoring wades into the unknown and alerts us to unusual disease outbreaks. The microbiologist, of the University College Dublin, heads Ireland’s wastewater surveillance program. Ideally, in this ahead-of-the-curve future, after detecting something alarming in sewage, his team could closely collaborate with health officials to study the pathogen and, if necessary, start combating the threat.
One idea for turning the tech proactive is to prepare for new health threats that we can see coming. For example, Meijer and his colleagues are interested in screening Ireland’s sewage for the H5N1 bird flu, but they are not yet doing this testing.
Another approach takes advantage of genetic testing technology to look at everything in our waste. Kartik Chandran, an environmental engineer at Columbia University who has mapped sewers’ microbial ecosystems with this technique, describes it as “trying to shine the light more broadly” rather than looking where the light is already shining brightest.
Such an approach might identify new pathogens before sick people start going to the doctor’s office, potentially leading to an earlier public health response. But with health officials still unsure of how best to use wastewater data, much more basic research is needed first. “People think wastewater surveillance is the answer to everything, and clearly that’s not true,” says Kirby, of the CDC, reflecting concerns from the state and local officials that she collaborates with at NWSS. Before diving ahead into proactive surveillance, Kirby and her colleagues are working to set up basic wastewater standards and protocols for health agencies. Priorities include evaluating how sewage trends correlate to cases for different pathogens and developing standards for how to use the data.
The wastewater surveillance field also needs to keep growing if the goal is to monitor and contribute to global health, with more sites contributing data and more scientists to analyze it. All of this work requires sustained funding.
The CDC’s program so far has been funded by COVID-era legislation and will run out of money in 2025. While wastewater surveillance is more cost-effective than other types of testing, it still requires a lot of resources. Washington’s state health department, for example, paid Biobot more than $500,000 for a one-year sewage testing contract, while the CDC has paid the company more than $23 million since 2020 for its work with NWSS.
For the last few years, wastewater surveillance has been a giant, messy group project. Scientists have collaborated across fields and locations, across private and public institutions, through Zoom calls and through poop samples shipped on ice. They’ve shown that waste might hold the key to a new way of tracking our collective health.
A lot of unanswered questions remain, and it could be some time before your local sewer can tell you exactly what disease risks you might be facing. But COVID-19 pushed thousands of experts to look into their toilets and start asking those questions. “Now, everyone’s a believer,” says Driver, of ASU. “Everyone’s doing the work.”
Chinese President Xi Jinping on Saturday urged firmly grasping the strategic positioning of Xinjiang in the overall national situation and better building a beautiful Xinjiang in the process of pursuing Chinese modernization.
Xi, also general secretary of the Communist Party of China (CPC) Central Committee and chairman of the Central Military Commission, made the remarks when he was briefed in Urumqi about the work of the Party committee and government of northwest China's Xinjiang Uygur Autonomous Region, as well as the Xinjiang Production and Construction Corps.
He demanded thorough, meticulous, concrete and sustained efforts to develop a beautiful Xinjiang that is united, harmonious, prosperous, and culturally advanced, with healthy ecosystems and people living and working in contentment, in the process of pursuing Chinese modernization.
Xi was in Xinjiang after returning to China from the 15th BRICS Summit and a state visit to South Africa.
Recognizing Xinjiang's achievements in various aspects, Xi said the work related to Xinjiang is of special importance in the work of the Party and the country, and concerns the overall task of building China into a strong modern socialist country in all respects and promoting the rejuvenation of the Chinese nation.
Efforts should be made not only to address prominent problems currently constraining Xinjiang's development and stability, but also to make long-term arrangements to promote fundamental, basic and long-term work for enduring prosperity and stability in the region, he said.
Maintaining social stability is a top priority, Xi said, urging efforts to coordinate the work of maintaining stability and advancing development, the two aspects that are mutually promoted. He also called for efforts to enhance the rule of law to build a solid legal foundation for enduring stability.
The mechanism for forestalling and defusing major risks and potential dangers should be improved, Xi said, adding that the fight against terrorism and separatism should be integrated with law-based and constant work of maintaining stability.
Forging a strong sense of community for the Chinese nation is a focus of the CPC's work on ethnic affairs in the new era and all work in areas with large ethnic minority populations, Xi said.
He said the education on standard spoken and written Chinese must be resolutely carried out to enhance people's consciousness and capability to use it.
He also stressed the importance of strengthening the protection and use of cultural relics and heritage to help officials and the public develop an accurate understanding of state, ethnicity, history, and religions.
Xi called for enhanced education on modern civilization and science among the youth and teenagers and encourage them to get involved in modern life. He emphasized advancing people-centered new urbanization and promoting exchanges and interactions among all ethnic groups.
Xi said Xinjiang should take the initiative in grasping fresh opportunities arising from the nation's drive to create a new development pattern, advance high-quality development and push for Chinese modernization.
Xinjiang should advance innovation in science and technology, foster and develop industries with unique advantages, and actively develop emerging industries. Efforts should be made to accelerate the construction of a modern industrial system that reflects Xinjiang's characteristics and strengths, and help Xinjiang advance on the track of high-quality development, he said.
To achieve social stability and high-quality development in Xinjiang, the most arduous task is in rural areas, Xi said, emphasizing the work to consolidate and build on the achievements of poverty alleviation and promote rural revitalization.
He called for more industrial cooperation and personnel exchange between Xinjiang and the rest of the country, and encouraged people from Xinjiang to work outside the region and people in other parts of the country to start business and live in Xinjiang.
With unique geographical advantages, Xinjiang should accelerate the construction to make itself the gateway of China's westward opening up, Xi said.
Xi asked Party members and officials to stay engaged with the people and their communities. He said Party organizations at the primary level must be strengthened to learn about the people's concerns and timely respond to their difficulties and problems.
He stressed the need to better tell Xinjiang stories in the new era through multiple channels to show an open and confident Xinjiang, while refuting fake and baleful statements targeting Xinjiang.
Xinjiang will open more widely for tourism and encourage domestic and overseas tourists to travel in the region, he said.
Xi stressed upholding the Party's overall leadership and strengthening the Party building in Xinjiang. He underscored the importance of resolutely upholding the Party Central Committee's authority and its centralized, unified leadership.
Cai Qi, a member of the Standing Committee of the Political Bureau of the CPC Central Committee and a member of the Secretariat of the CPC Central Committee, attended the briefing.
Japanese great tits (Parus minor) communicate using at least 10 different notes on their own and in combination. Researchers played different calls for Japanese great tits in a forest in Nagano, Japan, to see how the birds responded — an indication of what the call might mean. The birds responded differently to individual notes than they did when played the same note in combination with other notes. And, when researchers reversed the note order, the birds didn’t respond the same way. By itself, a note means one thing to great tits, but in combination, it means something different, the team argues March 8 in Nature Communications. Similarly, among humans, the order of words in a sentence, its compositional syntax, matters.
Some primates combine calls to convey different messages, but individual notes don’t carry unique meaning in these species. Great tits are the first nonhuman species shown to use compositional syntax, the researchers write. In this recording, researchers played three types of calls for Japanese great tits: First, a call with three notes — A, B, and C — which signals danger; second, a one-note call (D), which attracts mates; and finally, a combination call, ABC-D, which causes the birds to scan the skies for predators and fly to the source of the sound. Researchers played an ABC-D call for great tits, and then reversed an ABC-D call. Birds responded differently in each case.
In a pair of twin sisters, a rare disease had damaged the brain’s structures believed necessary to feel fear. But an injection of a drug could nevertheless make them anxious.
The results of that experiment, described in the March 23 Journal of Neuroscience, add to evidence that the amygdalae, small, almond-shaped brain structures tucked deep in the brain, aren’t the only bits of the brain that make a person feel afraid. “Overall, this suggests multiple different routes in the brain to a common endpoint of the experience of fear,” says cognitive neuroscientist Stephan Hamann of Emory University in Atlanta. The twins, called B.G. and A.M., have Urbach-Wiethe disease, a genetic disorder that destroyed most of their amygdalae in late childhood. Despite this, the twins showed fear after inhaling air laden with extra carbon dioxide (an experience that can create the sensation of suffocating), an earlier study showed (SN: 3/23/13, p. 12). Because carbon dioxide affects a wide swath of the body and brain, scientists turned to a more specific cause of fear that stems from inside the body: a drug called isoproterenol, which can set the heart racing and make breathing hard. Sensing these bodily changes provoked by the drug can cause anxiety.
“If you know what adrenaline feels like, you know what isoproterenol feels like,” says study coauthor Sahib Khalsa, a psychiatrist and neuroscientist at the Laureate Institute for Brain Research in Tulsa, Okla.
After injections of isoproterenol, both twins felt shaky and anxious. B.G. experienced a full-blown panic attack, a result of the drug that afflicts about a quarter of people who receive it, says Khalsa. In a second experiment, researchers tested the women’s ability to judge their bodies’ responses to the drug. While receiving escalating doses, the women rated the intensity of their heartbeats and breathing. A.M., the woman who didn’t have a panic attack, was less accurate at sensing the drug’s effects on her body than both her sister and healthy people, researchers found.
It’s not clear why the twins responded differently, Khalsa says. Further experiments using brain scans may help pinpoint neural differences that could be behind the different reactions.
The results suggest that the amygdala isn’t the only part of the brain involved in fear and anxiety, but there’s more work to do before scientists understand how the brain creates these emotions, Khalsa says. “It’s definitely a complicated question and a debate that’s unresolved,” he says.
Despite massive public health campaigns, the rise in worldwide obesity rates continues to hurtle along like a freight train on greased tracks.
In 2014, more than 640 million men and women were obese (measured as a body mass index of 30 or higher). That’s up from 105 million in 1975, researchers estimate in the April 2 Lancet. The researchers analyzed four decades of height and weight data for more than 19 million adults, and then calculated global rates based on population data. On average, people worldwide are gaining about 1.5 kilograms per decade — roughly the weight of a half-gallon of ice cream. But the road isn’t entirely rocky. During the same time period, average life expectancy also jumped: from less than 59 years to more than 71 years, George Davey Smith points out in a comment accompanying the new study. Smith, an epidemiologist at the University of Bristol in England, boils the data down to a single, seemingly paradoxical sentence: “The world is at once fatter and healthier.”
Bees may need their own supplemental protein shakes as increasing carbon dioxide in the atmosphere saps the nutritional quality of pollen.
Pollen collected from plants gives bees their only natural source of protein (nectar is a sugar-shot for energy). Yet protein content in pollen of a widespread goldenrod species (Solidago canadensis) dwindled by a third, from about 18 percent to 12 percent, over 172 years, according to analysis of recently collected flowers and of preserved specimens at the Smithsonian Institution’s National Museum of Natural History. During those same years, CO2 concentrations in the atmosphere increased from about 280 parts per million to 398 ppm, researchers report April 12 in Proceedings of the Royal Society B. The same themes also showed up in two years of growing the goldenrod at CO2 concentrations up to 500 ppm. More CO2 meant less concentrated protein in pollen, say Lewis Ziska of the U.S. Department of Agriculture’s Bee Research Laboratory in Beltsville, Md., and his colleagues.
“It’s like you’re eating a starchier diet — what would that do to us?” says study coauthor Joan Edwards of Williams College in Williamstown, Mass. “Bees aren’t so different.”
Bees, wild or domesticated, need adequate protein to feed their larvae, maintain their immune systems and for many more functions, says bee biologist Cédric Alaux of the French agricultural research agency INRA in Avignon. Canada goldenrod is an example of a species known to offer pollen that can be stored to tide honeybees over the winter. The one-third decrease in protein concentration reported in the new study is big enough to shorten bee life spans, he says.
Lower quality in bee food sources could be contributing to global bee declines observed in recent years and the uncertain state of pollination for crops, Edwards says. “The health of the bee population is not just for the flowers and the bees and biodiversity, but also for human health and well-being.”
Buying a handgun in Connecticut means waiting — lots of waiting. First comes an eight-hour safety course. Then picking up an application at a local police department. Review of the application (which includes a background check and fingerprinting) can take up to eight weeks. If approved, the state issues a temporary permit, which the buyer trades in at state police headquarters for a permanent one. Then it’s back to the store for the gun.
Head west to Missouri, though, and buying a handgun is practically a cakewalk. Customers at Osage County Guns in Belle, Mo., for example, can walk into the store and walk out with a gun if they pass the FBI’s instant background check, says John Dawson, the store’s chief technical officer. “If a person knew exactly what they wanted,” he says, the store could, “in theory, complete the transaction in about 15 minutes.”
Missouri and Connecticut have staked out opposite ends of the gun law spectrum. Connecticut didn’t require handgun buyers to get a permit until 1995. Missouri had a tough law on the books, but repealed it in 2007. The states’ laws have flip-flopped, making for a fascinating natural experiment on gun laws’ effects on gun violence.
The states “had mirror image policy changes, and mirror image results,” says Daniel Webster, a health policy researcher at Johns Hopkins University.
Flipping the laws was associated with 15 percent fewer gun suicides in Connecticut and 16 percent more in Missouri, a statistical analysis by Webster and colleagues, published last year in Preventive Medicine, estimated. Similar analyses by Webster in 2014 and 2015 indicated a 40 percent reduction in Connecticut gun homicide numbers, and an 18 percent rise in Missouri. The evidence is very suggestive, says Harvard University researcher David Hemenway. But it’s not extensive enough to persuade everyone — or to move national policy.
In fact, questions loom about the impact of all sorts of policies, from background checks to assault weapons bans to gun buybacks. That’s partly because gun research faces roadblocks at every turn: Scientists have to deal with data shutouts, slashed funding and, occasionally, harassment.
For a few questions, however, researchers have come up with solid answers: There’s a convincing link between gun availability and gun suicide, for one. And studies from the United States and abroad suggest that some gun laws do rein in gun violence. To make firm conclusions, though, scientists are desperate for more data.
But the U.S. Centers for Disease Control and Prevention can’t collect gun data like it used to, and information about guns used in individual crimes is locked up tight. Under current federal laws, Hemenway says, “It’s almost impossible for researchers to get even the data that are available.”
Locked up In a squat brick building tucked in the hills of Martinsburg, W. Va., gun data are overflowing.
Thousands of cardboard boxes, stacked high in tidy columns, line the hallways of the federal government’s National Tracing Center. In the parking lot, steel shipping containers hold even more boxes. Each box contains about 2,000 pages of gun purchase records. To trace a gun, the center’s employees often search through these records by hand.
That’s their job: tracking when and where guns used in crimes were originally purchased, and by whom. It’s a huge undertaking: In 2015, the center, part of the Bureau of Alcohol, Tobacco, Firearms and Explosives, or ATF, received more than 373,000 gun trace requests from law enforcement. Such a mass of data is a researcher’s dream. But current laws keep gun traces secret. The agency shares traces only with law enforcement. The public can see just summaries or aggregate data.
Webster has used this data to paint a rough picture of how Missouri’s repeal affected the flow of guns to criminals. In 2006, when buying a handgun required a permit, 56.4 percent of guns recovered by police had been originally sold by a Missouri gun dealer. In 2012, five years after the state nixed the permit requirement, the number rose to 71.8 percent, Webster and colleagues reported in the Journal of Urban Health in 2014.
The findings suggest that it’s easier now for criminals in Missouri to get their hands on legally purchased guns. But Webster can’t say for certain whether more guns are moving to criminals — or whether legal gun owners are committing more crimes. For that, he’d need to see the individual gun traces.
About a decade ago, researchers who wanted such detailed data could get it. “We’d just hand them a DVD,” says ATF information specialist Neil Troppman. “Those days are long over.”
A handful of laws snarl the process, from how a gun trace begins to who can see the data.
One big hitch in the system: Police officers who find a gun at a crime scene can’t always look up the owner’s name on a computer. That’s because there is no national registry — no searchable database of guns and their owners. To set one up would be illegal. So police have to submit a request to the tracing center, which tracks the gun’s movement from manufacturer or importer to dealer. Then the ATF can ask the dealer who bought the gun. If the dealer has gone out of business, ATF employees dig for the answer themselves, in old gun purchase records stockpiled at the tracing center. The process takes an average of five days. And after law enforcement gets the data, federal law makes sure no one else can see it.
Federal constraints In 2003, Congress unleashed a beast of a bill with an amendment that effectively tore out the ATF’s tongue. The Tiahrt amendment was the first in a series of provisions that drastically limited the agency’s ability to share its crime gun data — no giving it to researchers, no making it public, no handing it over under Freedom of Information Act requests (the public’s channel for tapping into information from the federal government).
Funding for gun control research had dried up a few years earlier. There’s no outright ban, but a 1996 amendment had nearly the same effect. It’s known as the Dickey amendment, and it barred the CDC from using funds to “advocate or promote gun control.” According to a 2013 commentary in JAMA, that meant almost any research on guns. If the 1996 law’s language was vague, Congress made the message clear by cutting the CDC’s budget by $2.6 million — exactly the same amount the agency had spent the previous year on gun violence research. The funds were later reinstated, but earmarked for other things. So the CDC largely backed off, except for some basic tallying, says spokesperson Courtney Lenard, because of the funding cuts and because Congress “threatened to impose further cuts if that research continued.”
In 2011, Congress hit the National Institutes of Health with similar restrictions. About a year later, President Obama tried to ease the choke hold: He ordered the CDC to research the causes and prevention of gun violence, and called on Congress to provide $10 million in funding. Finally, 17 years after the CDC cuts, news reports proclaimed that the ban had been lifted and research could resume. But Congress never authorized the money, and the CDC remained on the sidelines. This April, nearly 150 health and science organizations, universities and other groups signed a letter urging Congress to restore the CDC’s funding.
Meanwhile, research on gun violence and gun control trudges forward: Researchers can sometimes convince law enforcement agencies to share data on guns linked to crimes, and grants can come from private foundations. Yet even with limits on research, the science in some cases is solid: A gun in the home, for example, increases the odds a person will commit suicide by about 3-to-1. Here, Hemenway says, “The weight of the evidence is overwhelming.”
But how to use laws to reduce gun violence remains hotly contested, and opinions among the public, and even scientists, are polarized.
Critics of gun control laws think the matter is clear: Again and again studies show that gun control policies just don’t work, says economist John Lott, who has written extensively on the subject. Take background checks, he says, “Given that these laws are costly, you’d like to believe there’s some evidence that they produce a benefit.”
Webster acknowledges the divisive split in opinions. “The vast majority of people are on one side of the fence or the other,” he says. “They’ll point to a study that is convenient to their political arguments and call it a day.”
Bad for your health For researchers who manage to navigate the legal tangles and funding troubles of gun research, actually doing the research itself isn’t easy.
Unlike clinical trials in medicine, where scientists can give, for example, a cholesterol drug to half a study’s participants and then compare the effects between users and nonusers, scientists studying gun violence can’t dole out new handguns to one group and none to another and see what happens.
Instead, researchers turn to observational studies. That means looking at how — and if — suicides track with gun ownership in different groups of people and over time, for example. Finding a link between two observations doesn’t necessarily mean they’re connected. (People have linked the yearly number of Nicolas Cage movies to swimming pool drownings, after all.) But finding a lot of links can be telling.
For suicides, the link to gun access holds strong — among old people, young people, women, adolescents, “you name it,” Hemenway says. Lots of guns means lots of suicides by gun, he says. In 2007, Hemenway and colleagues examined gun ownership rates and statewide suicide data from 2000 to 2002. People in states with a high percentage of gun owners (including Wyoming, South Dakota and Alaska) were almost four times as likely to kill themselves with guns as people living in states with relatively few gun owners (such as Hawaii, Massachusetts and Rhode Island), the researchers reported in the Journal of Trauma Injury, Infection and Critical Care.
More recently, a 2013 study in Switzerland compared suicide rates before and after an army reform that cut the number of Swiss soldiers by half. After the reform, fewer people had access to army-issued guns — and the suicide rate dipped down by about two per 100,000 men age 18–43. That’s about 30 men each year who didn’t die from suicide, the study’s authors estimated in the American Journal of Psychiatry.
A 2014 review of 16 such studies, published in the Annals of Internal Medicine, came to the same conclusion, again: Access to guns meant higher risk of suicide.
“The evidence is unassailable,” says Stanford University criminologist John Donohue. “It’s as strong as you can get.”
Mental illness factors into suicide too, says Jeffrey Swanson, a medical sociologist at Duke University. (Some 21 to 44 percent of suicides reported to the CDC are committed by people with mental health problems.) And federal laws aren’t particularly good at keeping guns away from mentally ill people. A 1968 law prohibits gun sales to a narrow slice of people with a history of mental illness, but it’s easy for others to slip through the cracks. Even people the law does target can end up with guns — because states don’t have to report mental health records to the FBI’s national background-check system.
“You’ve got tons of records that would disqualify people from buying guns,” Swanson says, but they don’t necessarily make it into the system. Even if the United States had a perfect mental health care system and cured schizophrenia and bipolar disorder and depression, he says, the overall problem of gun violence would still exist. Mentally ill people just aren’t that violent toward others, Swanson noted in the Annals of Epidemiology in 2015. In fact, people with mental illness committed fewer than 5 percent of U.S. gun killings between 2001 and 2010, according to the CDC.
“People think that in order to fix gun violence, we need to fix the mental health care system,” Swanson says. That’s wrong, he argues. “It’s a diversion from talking about guns.”
Weak laws After Sandy Hook, San Bernardino and other high-profile mass shootings, people have been talking about what gun control laws, if any, actually work.
Unfortunately, there’s just not enough evidence to make strong conclusions about most laws, Hemenway says. In 2005, for example, a federal task force reviewed 51 studies of gun laws, mostly in the United States, and came up empty-handed. The task force couldn’t say whether any one of the laws made much of a difference. The efficacy of U.S. gun laws is hard to pin down for two main reasons, Hemenway says: Gun laws aren’t typically very strong, and studies tend to look at overall effects on violence.
One major study published in JAMA in 2000 analyzed suicide and homicide data from 1985 to 1997 to evaluate the impact of the Brady Act, a 1994 federal law that requires background checks for people buying guns.
Eighteen states and the District of Columbia already followed the law. So researchers compared suicide and homicide rates with those in the 32 states new to the law. If Brady curbed gun violence, those 32 states should see dips in deaths. That didn’t happen (with one exception: Gun suicides in those states dropped in people age 55 and older — by about 1 per 100,000 people).
“I don’t think anybody was really shocked,” Webster says. After all, Brady had a gaping hole: It didn’t require background checks for guns bought from private sellers (including those at gun shows). The loophole neutered Brady: People who didn’t want a background check could simply find a willing private seller. That’s just too easy, Webster says: It’s like letting people decide whether they want to go through the metal detector at the airport.
Like the Brady Act, the 1994 Federal Assault Weapons Ban didn’t seem to do much to prevent violence, criminologist Christopher Koper and colleagues concluded in a 2004 report to the U.S. Department of Justice. The law, which expired in 2004, imposed a 10-year ban on sales of military-style semiautomatic guns. These weapons fire one bullet per trigger squeeze and have features like threaded barrels (which can be used for screwing on silencers) or barrel mounts (for attaching bayonets). The 1994 law also banned most large-capacity magazines (storage devices that feed guns more than 10 rounds of ammo).
But like Brady, the ban came with a catch: It didn’t apply to weapons and magazines made before September 13, 1994. That’s a lot of exemptions. At the time, the United States had more than 1.5 million assault weapons and nearly 25 million guns with large-capacity magazines, reported Koper, of George Mason University in Fairfax, Va.
“The more complete the bans are, the better the effects seem to be,” Donohue says. Take Australia: In 1996, the country enacted strict laws and a gun buyback program after a mass shooting killed 35 people in Tasmania. The ban made certain long-barreled guns illegal (including semiautomatic rifles and pump-action shotguns — weapons that let people fire lots of rounds quickly), and the country bought back and destroyed more than 650,000 guns.
With the law, Donohue says, “Australia effectively ended the problem of mass shootings.”
And as economists Christine Neill and Andrew Leigh found, the law drastically cut down the number of gun suicides, too. Tough laws Eleven years after Australia launched its tough gun control legislation, Neill, of Wilfrid Laurier University in Canada, and Leigh, then at Australian National University in Canberra, announced that the law might actually be saving lives.
Critics attacked. One petitioned Neill’s university to reprimand her. Then they came for Leigh’s e-mails. He had to hand over any that mentioned firearms or guns. Had there been anything improper — any whiff that the researchers were biased — Neill believes gun advocates would have pounced.
Neill and Leigh, now an Australian politician, had uncovered telling changes in different regions’ suicide rates between 1990–1995 and 1998–2003. “Firearms suicides fell most in Tasmania, by a long shot,” Neill says, almost 70 percent, the team later reported in 2010 in the American Law and Economics Review.
Australia’s law, called the National Firearms Agreement, or NFA, applied to all of the country’s states and territories, but some had more guns than others. Tasmania, for example, had the most guns bought back, Neill says: 7,302 guns per 100,000 people. More guns bought back meant bigger drops in suicide rates, she says. Instead, the United States goes for smaller laws, fashioned mostly state-by-state. Still, some may be effective. Blocking domestic violence offenders’ access to guns seems to cut down on homicides, for example. From 1982 to 2002, states with restraining order laws that bar offenders from buying guns had rates of intimate partner homicide that were 10 percent lower than in states lacking the laws, researchers reported in 2006 in Evaluation Review.It’s a stark result, and suggests that tough laws can have big impacts. Australia “did an outright ban and something akin to a confiscation of guns,” Webster says. “That’s never going to happen in the United States.”
In 2010, Webster and colleagues reported similar results at the city level. He and colleagues tracked intimate partner homicides from 1979 to 2003 in 46 U.S. cities. Those that made it hard for people with domestic violence restraining orders to get guns had 19 percent fewer intimate partner homicides compared with cities with less stringent laws, the team reported in Injury Prevention.
“These are pretty consistent findings,” Webster says. Those state policies seem to be working.
Conclusions about other, more well-known laws, such as “right-to-carry,” are less convincing. Such laws, which allow people to carry concealed handguns in public, could offer people a means of defense. Or they could make it easier for people in an argument to whip out a gun. “The findings are all over the map,” Hemenway says. A report from the National Research Council in 2005 found no causal link between right-to-carry laws and crime. It also concluded that people do use guns to protect themselves (say, by threatening or shooting an attacker) but how often is hard to say. Estimates vary from 100,000 to 2.5 million times per year in the United States.
Economist Mark Gius of Quinnipiac University in Hamden, Conn., estimated that restricting people’s right to carry boosts a state’s murder rate by 10 percent, he reported in 2014 in Applied Economics Letters.
Donohue’s 2014 results lean a different way. The Stanford researcher updated the NRC analysis with more than a decade of new data and found that laws letting people carry concealed weapons boost violent crime — a bit. Based on data from 1979 to 2012, his statistical modeling showed that a state with a right-to-carry law would experience 8 percent more aggravated assaults than a state without such a law, for example.
“More and more evidence is amassing that these laws are harmful,” Donohue says, but he concedes that there’s still uncertainty. “I’m not quite ready to say that we’ve nailed it down.”
Less uncertainty would require more analyses and more data. But in this field, even that doesn’t guarantee consensus.
“The problem is that there are many ways to slice the data,” Donohue says. “Almost nothing is as clear as the advocates make it — on both sides.”
Shaken-but-not-stirred remnants of Earth’s earliest years still exist nearly 4.6 billion years later.
Researchers traced the shadowy footprints of an isotope that hasn’t existed for over 4.5 billion years to much younger lava rocks from the Pacific and Atlantic oceans. That suggests that reservoirs of the ancient mantle may be hidden deep inside the planet, geochemist Hanika Rizo and colleagues report May 13 in Science.
Earth formed about 4.6 billion to 4.5 billion years ago as planetary bodies collided, disintegrating and melting to accrete into one mass like a hot, rocky lint ball. Geologists have assumed that any relics of this bumpy beginning were mixed beyond recognition. Instead, Rizo’s team found a surprise: Some modern flood basalts have unusually high concentrations of tungsten-182. That’s significant because that isotope forms only from radioactive decay of hafnium-182. And hafnium-182 only existed during Earth’s first 50 million years. “These isotopes had to be created early,” says Rizo, of the University of Quebec in Montreal. It is “spectacular” that some of Earth’s earliest materials may still be preserved, says Matthias Willbold, a geochemist at the University of Manchester in England. “We may have to revise our view of the Earth’s internal structure.”
Rizo and colleagues measured the tungsten-182 in flood basalts from two locations: Canada’s Baffin Bay, part of the 60-million-year-old North Atlantic Igneous Province, and near the Solomon Islands, part of the 120-million-year-old Ontong Java Plateau in the Pacific Ocean. “Flood basalts are not normal eruptions,” Rizo says. “They are capable of tapping into the deep mantle.” Her team found that levels of tungsten-182 in the lavas varied, suggesting that the deep sources of these younger rocks were different pieces of Earth’s oldest material, each with their own isotopic signature and history. These results also show that the ancient remnants have somehow escaped being mixed by convection currents.
Geophysicists have identified two large “blobs” in the deep mantle, called large low-shear velocity provinces. Those blobs “could be candidates” for the remnants of the ancient mantle, Rizo says.
